纤维蛋白原/白蛋白比值血小板参数与冠状动脉病变程度相关性研究

doi:10.3969/j.issn.1006-6233.2025.08.024

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Abstract Objective: To explore the correlation of fibrinogen to albumin ratio (FAR) and platelet parameters with degree of coronary artery lesion. Methods: The clinical data of 154 patients who received coronary angiography in the hospital were retrospectively analyzed from January 2021 to August 2024. The enrolled patients were assigned into coronary heart disease (CHD) group (n=108) and reference group (n=46) by coronary angiography results. By means of the evaluation results of Gensini score system, the patients in the CHD group were classified into mild-to-moderate lesion group (80 cases, Gensini score<60 points) and severe lesion group (28 cases, Gensini score≥60 points). The FAR and platelet parameters were compared among the reference group, mild-to-moderate lesion group and severe lesion group. The correlation of FAR and various platelet parameters with coronary artery lesion degree was explored by Spearman correlation coefficient. The area under the receiver operating characteristic (ROC) curve (AUC) was used to test the value of combination of FAR and platelet parameters in assessing the degree of coronary artery lesion. Results: The FAR, MPV and PDW in the mild-to-moderate lesion group and the severe lesion group were higher than those in the reference group, and the above indicators in the severe lesion group were higher compared with those in the mild-to-moderate lesion group (P<0.05). PLT was lower in the mild-to-moderate lesion group and the severe lesion group than that in the reference group, and was also lower in the severe lesion group compared to the mild-to-moderate lesion group (P<0.05). Spearman correlation coefficient analysis revealed that FAR, MPV and PDW were positively correlated with coronary artery lesion degree (r=0.473, 0.451, 0.468, P<0.05), and PLT was negatively associated with the degree of coronary artery lesion (r=-0.397, P<0.05). According to the AUC predictive value under the ROC curve, the AUC of FAR combined with platelet parameters was 0.938 (95%CI: 0.881~0.994) in assessing the degree of coronary artery lesion (P<0.05). Conclusion: FAR and platelet parameters are significantly correlated with the degree of coronary artery lesion, and the combined detection of various indicators is effective in predicting coronary artery lesion in CHD. These indicators can be comprehensively analyzed as the preferred biomarkers for clinical diagnosis of coronary artery disease and coronary artery lesion degree.

Key words： Coronary artery lesion Fibrinogen to albumin ratio Platelet parameters Correlation

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.08.024 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I8/1364

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