关节囊厚度血清IL-1β COX-2与粘连性肩关节炎病情程度相关性及其诊断价值

doi:10.3969/j.issn.1006-6233.2025.08.025

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Abstract Objective: To investigate the thickness of the inferior capsule (IC) of the glenohumeral joint in adhesive shoulder arthritis, the levels of serum interleukin-1β (IL-1β) and cyclooxygenase-2 (COX-2), and analyze their correlation with disease severity and diagnostic value for adhesive shoulder arthritis. Methods: A total of 210 patients with adhesive shoulder arthritis from July 2022 to July 2024 were selected as the study group, and 105 healthy volunteers during the same period were selected as the control group. The IC thickness, serum IL-1β, and COX-2 levels were compared between the two groups. The Constant-Murley Shoulder Function (CMS) score and Visual Analogue Scale (VAS) score were used as the basis for evaluating the severity of the disease, and were divided into four subgroups. IC thickness, serum IL-1β, and COX-2 levels were compared. The diagnostic value of IC thickness, serum IL-1β, and COX-2 levels was analyzed for adhesive shoulder arthritis. Correlation analysis was used to analyze the correlation between IC thickness, serum IL-1β, COX-2 levels, and CMS scores and VAS scores. Results: The thickness of the IC on the affected side of the study group was greater than that on the left side of the control group (3.35±0.94mm vs 1.26±0.27mm, t=22.312, P<0.001), and on the right side of the control group (3.35±0.94mm vs 1.20±0.24mm, t=23.048, P<0.001); the thickness difference between the two sides of the IC in the research group was greater than that in the control group (2.14±0.63 mm vs 0.06±0.02 mm, t=33.796, P<0.001); the levels of serum IL-1β and COX-2 in the study group were (28.15±9.85) ng/mL and (23.69±7.28) pg/mL, respectively, which were higher than those in the control group at (13.64±4.17) ng/mL and (12.41±4.05) pg/mL (P<0.05). The thickness of the affected side of the IC, serum levels of IL-1β, and COX-2 showed a gradual downward trend in C1, C2, C3, and C4 subgroups, while the thickness of the affected side of the IC, serum levels of IL-1β, and COX-2 showed a gradual upward trend in V1, V2, V3, and V4 subgroups (P<0.05). The AUC of IC thickness, serum IL-1β, COX-2 levels, and their combined diagnosis for adhesive shoulder arthritis on the affected side were 0.776, 0.770, 0.753, and 0.923, with sensitivities of 80.48%, 69.52%, 64.29%, and 80.00%, and specificities of 61.90%, 74.29%, 74.29%, and 91.43%. The combined diagnostic value was significantly higher than that of each individual indicator (Z=4.896, 4.871, 5.439, all P<0.001). The contingency correlation analysis showed that the thickness of the affected side of the IC, serum IL-1β, and COX-2 levels were negatively correlated with CMS scores and positively correlated with VAS scores (P<0.05). Conclusion: The thickness of IC in patients with adhesive shoulder arthritis increases, and the levels of serum IL-1β and COX-2 increase, which are closely related to the severity of the disease. Combined detection of their levels has certain diagnostic value for adhesive shoulder arthritis, and combined detection can improve diagnostic efficiency.

Key words： Adhesive shoulder arthritis Glenohumeral joint Thickness of the inferior capsule Interleukin-1β Cyclooxygenase 2 Diagnostic value

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.08.025 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I8/1369

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