Abstract：Objective: To analyze peripheral blood immunoglobulin E (IgE) and 25-hydroxyvitamin D [25-(OH)-D], electroencephalogram (EEG) changes in relation to prognosis in children with tic disorders (TD). Methods: Totally 102 children with TD admitted to the hospital from May 2021 to March 2024 were retrospectively selected. According to the Yale Global Tic Severity Scale (YGTSS) score, children enrolled were divided into the mild to moderate group (YGTSS score ≤ 50) and the severe group (YGTSS score >50). The levels of IgE and 25-(OH)-D, and EEG examination results in the two groups were compared. After standardized treatment, the children were divided into good prognosis group and poor prognosis group based on the decrease in YGTSS score. Multivariate logistic regression analysis was performed to screen the prognostic factors for children with TD, and discuss their correlation with EEG examination results, IgE, and 25-(OH)-D. Results: Among 102 children with TD, 78 (76.47%) and 24 (23.53%) had mild to moderate and severe disease respectively. There were statistically significant differences in the rates of IgE, 25-(OH)-D and EEG abnormalities between the two groups. The abnormal rates of IgE and EEG in the severe group were significantly higher than those in the mild to moderate group, and 25-(OH)-D level was lower than the mild to moderate group (P<0.05). Among 102 children with TD, 41 had poor prognosis, accounting for 40.20%. IgE level, and abnormal rate of EEG in the poor prognosis group were significantly higher than those in the good prognosis group, and 25-(OH)-D level was significantly lower than that in the good prognosis group (P<0.05). Logistic analysis found that EEG examination results, IgE, and 25-(OH)-D were independent risk factors influencing the prognosis of TD (P<0.05). Conclusion: Peripheral blood IgE levels in children with TD are relatively high. Besides, the lower 25-(OH)-D level, the higher the abnormal rate of EEG. All of above indicators are closely related to the severity and prognosis of the disease. Detecting these indicators is of great significance for evaluating disease progression and therapeutic effects.
2025, Vol. 31 
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