小儿重症肺炎预后转归与MPV/PLT及炎症反应相关指标的关系及临床价值研究

doi:10.3969/j.issn.1006-6233.2025.06.17

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摘要 目的: 分析小儿重症肺炎预后转归与平均血小板体积(MPV)/血小板计数(PLT)及炎症反应相关指标的相关性,并评价其对小儿重症肺炎预后转归的预测价值。方法: 将2022年7月至2024年7月于本院就诊的115例重症肺炎患儿为研究对象。依据其预后转归情况分为预后良好组(n=87)与预后不良组(n=28),测定所有研究对象的MPV/PLT、乳酸脱氢酶(LDH)、降钙素原(PCT)、C反应蛋白(CRP)水平,以Logistic回归分析MPV/PLT、LDH、PCT、CRP水平与小儿重症肺炎预后转归的关联性;以受试者特征工作曲线(ROC)分析MPV/PLT、LDH、PCT、CRP水平对小儿重症肺炎预后转归的预测价值。结果: 预后不良组的MPV/PLT、LDH、PCT、CRP水平高于预后良好组(P<0.05)。Logistic回归分析显示,MPV/PLT、LDH、PCT、CRP水平与小儿重症肺炎预后转归密切相关(P<0.05);ROC曲线显示,MPV/PLT、LDH、PCT、CRP水平联合预测小儿重症肺炎预后转归的曲线下面积(AUC)为0.953,灵敏度为83.33%,特异度为97.01%,联合预测效能优于各指标单独预测(P<0.05)。结论: 小儿重症肺炎预后转归与MPV/PLT及炎症反应相关指标的关系密切,通过早期测定MPV/PLT、LDH、PCT、CRP水平可为临床预测重症肺炎患儿的预后转归情况提供一定的参考依据。

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	周贝贝
	李洁
	张萌

关键词 ：小儿重症肺炎, 预后转归, 平均血小板体积/血小板计数, 乳酸脱氢酶, 降钙素原, C反应蛋白

Abstract：Objective: To analyze the correlation of prognosis outcome of children with severe pneumonia (SP), with mean platelet volume (MPV)/platelet count (PLT) and inflammatory response-related indicators, and evaluate its predictive value on prognosis outcome in children with SP. Methods: Totally 115 children with SP in the hospital were selected from July 2022 to July 2024 as the study subjects. According to the prognosis outcome status, the patients were divided into good prognosis group (n=87) and poor prognosis (n=28) group. The levels of MPV/PLT, lactate dehydrogenase (LDH), procalcitonin (PCT) and C-reactive protein (CRP) were measured among all study subjects. Logistic correlation analysis was applied to analyze the association between MPV/PLT, LDH, PCT and CRP levels and prognosis outcome of SP children. The predictive value of MPV/PLT, LDH, PCT and CRP on the prognosis outcomes of SP in children was analyzed by receiver operating characteristic curve (ROC). Results: The MPV/PLT, LDH, PCT and CRP in the poor prognosis group were higher than those in the good prognosis group (P<0.05). Logistic correlation analysis demonstrated that MPV/PLT, LDH, PCT and CRP levels were closely correlated with the prognosis outcome of SP children (P<0.05). ROC curve indicated that the area under the curve (AUC), sensitivity and specificity of MPV/PLT, LDH, PCT and CRP in predicting the prognosis outcome were 0.953, 83.33% and 97.01%. The efficiency of combined prediction was better than that of each indicator alone (P<0.05). Conclusion: The prognosis outcome of SP in children is closely related to MPV/PLT and inflammatory response-related indicators. Early determination of MPV/PLT, LDH, PCT and CRP levels can provide a certain reference for clinical prediction of prognosis outcome of children with SP.

Key words： Severe pneumonia in children Prognosis outcome Mean platelet volume/platelet count Lactate dehydrogenase Procalcitonin C-reactive protein

基金资助:安徽省卫生健康科研项目,(编号:AH2022WJGc0043)

引用本文:

周贝贝, 李洁, 张萌. 小儿重症肺炎预后转归与MPV/PLT及炎症反应相关指标的关系及临床价值研究[J]. 河北医学, 2025, 31(6): 969-973.
ZHOU Beibei, LI Jie, ZHANG Meng. Study on the Relationship and Clinical Value of Prognostic Regression of Paediatric Severe Pneumonia with MPV/PLT and Inflammatory Response Related Indexes. HeBei Med, 2025, 31(6): 969-973.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2025.06.17 或 http://www.hbyxzzs.cn/CN/Y2025/V31/I6/969

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