Abstract：Objective: To explore the relationship between the combined detection of serum homocysteine (Hcy) and beta-trace protein (BTP) levels and the pregnancy outcomes of patients with severe preeclampsia (PE). Methods: A total of 320 PE patients from January 2021 to January 2024 were selected as the PE group, and 275 normal pregnant women during the same period were selected as the control group. According to the severity of PE, they were divided into the mild-to-moderate group (n=184) and the severe group (n=136). Then, the patients with severe PE were further divided into the favorable group (n=94) and the unfavorable group (n=42) according to the pregnancy outcomes. The serum Hcy and BTP levels were detected by ELISA from the 11th to 13th week of pregnancy. The predictive value of serum Hcy and BTP levels for the unfavorable pregnancy outcomes of patients with severe PE was analyzed by the ROC curve, and the Z-test was used to compare the differences in the area under the curve (AUC). Results: The levels of Hcy (18.06±4.38 μmoL/L) and BTP (4.44±1.15 ng/mL) in the PE group were higher than those in the control group (12.75±3.24 μmoL/L, 3.15±0.95ng/mL) (t=16.580, 14.768, all P<0.05). The levels of Hcy (21.56±5.42 μmoL/L) and BTP (5.38±1.31 ng/mL) in the severe group were higher than those in the mild-to-moderate group (15.47±4.13 μmoL/L, 3.75±0.84ng/mL) (t=13.532, 11.108, all P<0.05). The total proportion of unfavorable pregnancy outcomes in the severe group (30.88%) was higher than that in the mild-to-moderate group (17.39%) (χ2=8.006, P<0.05). The levels of Hcy (21.15±6.24 μmoL/L) and BTP (5.74±1.68 ng/mL) in the unfavorable group were higher than those in the favorable group (16.68±3.58 μmoL/L, 3.86±1.07 ng/mL) (t=5.280, 7.866, P<0.05). The AUCs of Hcy and BTP alone in predicting the unfavorable pregnancy outcomes of patients with severe PE were 0.798 and 0.803, respectively, and the AUC of the combined diagnosis of the two was 0.906, which was superior to the individual predictions (Z for the combination-Hcy=2.693, Z for the combination-BTP=2.853, P=0.007, P=0.004). Conclusion: The serum levels of Hcy and BTP increase with the aggravation of the severity of PE. Patients with severe PE have a relatively high risk of unfavorable pregnancy outcomes. The combined diagnosis of Hcy and BTP has certain value in predicting the unfavorable pregnancy outcomes of patients with severe PE, providing a data basis for clinical diagnosis and treatment.
杨子嫚, 崔艳杰, 李娜, 崔潇华. 血清Hcy BTP水平联合检测与重度子痫前期患者妊娠结局的关系研究[J]. 河北医学, 2025, 31(10): 1686-1691.
YANG Ziman, CUI Yanjie, LI Na, et al. Relationship between the Combined Detection of Serum Hcy and BTP Levels and the Pregnancy Outcomes of Patients with Severe Preeclampsia. HeBei Med, 2025, 31(10): 1686-1691.
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2025, Vol. 31 
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