Abstract：Objective: To compare the clinical efficacy of 3D modeling-assisted surgery and traditional craniotomy in the treatment of gliomas in functional areas, and to explore whether 3D modeling-assisted surgery has advantages. Methods: A total of 110 patients with gliomas admitted to our hospital from May 2022 to May 2025 were retrospectively enrolled and evenly assigned, according to the surgical approach, to an observation group (3D-modeling–assisted surgery, n = 55) or a control group (conventional craniotomy, n = 55). The two groups were compared in terms of operation duration, intraoperative blood loss, total tumor resection rate, KPS score of two weeks after surgery, serum inflammatory factor levels before and after surgery, clinical effective rate, complications, and adverse reactions. Results: In the observation group, the operation time, intraoperative blood loss, and length of hospital stay were all lower than those in the control group, while the resection rate and KPS score were higher than those in the control group, with significant differences (P<0.05). There was no significant difference in the overall incidence of complications between the two groups (P>0.05). TNF-α, IL-6, IL-1β and IFN-γ levels decreased from baseline in both the observation and control groups; the magnitude of change (pre- vs post-treatment) for every parameter was greater in the observation group than in the control group (P<0.05). Within each group, post-operative inflammatory mediator levels were significantly lower than pre-operative values (P<0.05). Baseline levels of IL-6, IL-1β and IFN-γ did not differ between the observation and control groups (P>0.05), whereas after treatment all three mediators were lower in the observation group than in the control group (P<0.05). The effective-response rate was higher in the observation group than in the control group (P<0.05), and the total incidence of adverse events was lower in the observation group (P<0.05). Conclusion: 3D modeling-assisted surgery shortens the operation time and hospital stay, reduces intraoperative blood loss, lowers the level of inflammatory factors, improves the resection rate of gliomas and the treatment efficiency of patients, and reduces the incidence of adverse reactions. It has the potential to be promoted and applied in clinical practice.
高宁茜, 师秋霞, 冶华玲, 赵洁, 范国锋. 3D建模辅助手术治疗功能区脑胶质瘤的临床疗效分析[J]. 河北医学, 2025, 31(11): 1835-1839.
GAO Ningxi, SHI Qiuxia, YE Hualing, et al. Analysis of Clinical Efficacy of 3D Modeling-Assisted Surgery in the Treatment of Gliomas in Functional Areas. HeBei Med, 2025, 31(11): 1835-1839.
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2025, Vol. 31 
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