Abstract：Objective: To investigate the predictive value of NOD-like receptor protein 3 (NLRP3), IL-1 receptor antagonist (IL-1Ra) and thioredoxin binding protein-2 (TBP-2) levels in gestational diabetes mellitus (GDM). Methods: A total of 103 GDM patients admitted to our hospital between November 2021 and December 2024 were selected as the GDM group while 52 healthy pregnant patients were chosen as the control group. The levels of NLRP3, IL-1Ra, TBP-2 and other clinical data were compared between the two groups. Binary Logistic regression analysis was used to screen the influencing factors of GDM, and ROC curve was used to verify its predictive performance. Results: Compared with the control group, the GDM group had more macrosomia, and the levels of FPG, TG, LDL-C, NLRP3, IL-1Ra and TBP-2 were increased. (P<0.05). FPG, TG, LDL-CNLRP3, IL-1Ra and TBP-2 were independent risk factors for GDM (P<0.05). ROC curve analysis showed that the area under the curve of single and combined detection of NLRP3, IL-1 Ra and TBP-2 levels in the diagnosis of GDM was 0.639, 0.698, 0.645 and 0.785, respectively, and the combined detection had the highest efficiency. Conclusion: NLRP3, IL-1Ra and TBP-2 are closely related to the occurrence of GDM and have certain predictive value.
谢常山, 王琴, 王玉, 宋焕焕, 徐畅, 庄薇. NLRP3 IL-1Ra及TBP-2水平与GDM的关系及预测价值分析[J]. 河北医学, 2026, 32(1): 69-74.
XIE Changshan, WANG Qin, WANG Yu, et al. Analysis of the Relationship and Predictive Value of NLRP3 IL-1Ra and TBP-2 Levels in Gestational Diabetes Mellitus. HeBei Med, 2026, 32(1): 69-74.
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2026, Vol. 32 
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