脐动脉血气分析与新生儿缺氧缺血性心肌损伤的相关性研究

doi:10.3969/j.issn.1006-6233.2025.12.024

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摘要 目的: 探讨脐动脉血气分析与新生儿缺氧缺血性心肌损伤的相关性。方法: 选择本院2023年1月至2025年6月收治的110例新生儿作为研究对象,根据其是否发生缺氧缺血性心肌损伤,将其分为缺氧缺血性心肌损伤组(n=48)与非缺氧缺血性心肌损伤组(n=62)。比较两组临床资料及脐动脉血气分析水平,Pearson相关性分析分析脐动脉血气分析指标与心肌酶谱指标的关系。结果: 缺氧缺血性心肌损伤组较非缺氧缺血性心肌损伤组氢离子浓度指数(pH)、碱剩余(BE)、氧分压(PaO₂)、碳酸氢根(HCO₃^-)、钙离子、氯离子水平降低(P<0.05),二氧化碳分压(PaCO₂)、肌酸磷酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、α-羟基丁酸脱氢酶(HBDH)、谷丙转氨酶(ALT)水平升高(P<0.05)。Pearson相关性分析发现脐动脉血气分析与心肌酶谱指标密切相关(P<0.05)。结论: 脐动脉血气分析指标水平与新生儿缺氧缺血性心肌损伤密切相关。

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	史艳红
	辛海岩
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关键词 ：脐动脉血气分析, 新生儿缺氧缺血性心肌损伤, 相关性

Abstract：Objective: To investigate the correlation between umbilical artery blood gas analysis and neonatal hypoxic-ischemic myocardial injury. Methods: A total of 110 neonates admitted to our hospital from January 2023 to June 2025 were selected as the research objects. According to whether they had hypoxic-ischemic myocardial injury, they were divided into hypoxic-ischemic myocardial injury group (n=48) and non-hypoxic-ischemic myocardial injury group (n=62). The clinical data and umbilical artery blood gas analysis levels were compared between the two groups. The relationship between the umbilical artery blood gas analysis index and myocardial enzyme spectrum index was analyzed by Pearson correlation analysis. Results: The levels of hydrogen ion concentration index (pH), base excess (BE), partial pressure of oxygen (PaO₂), bicarbonate (HCO₃^-), calcium ion, and chloride ion in the hypoxic-ischemic myocardial injury group were lower than those in the non-hypoxic-ischemic myocardial injury group (P<0.05). The levels of partial pressure of carbon dioxide (PaCO₂), creatine phosphokinase (CK), creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH), α-hydroxybutyrate dehydrogenase (HBDH), and alanine aminotransferase (ALT) were increased (P<0.05). Pearson correlation analysis showed that umbilical artery blood gas analysis was closely associated with the myocardial enzyme spectrum index (P<0.05). Conclusion: The level of umbilical artery blood gas analysis index is closely associated with neonatal hypoxic-ischemic myocardial injury.

Key words： Umbilical artery blood gas analysis Neonatal hypoxic-ischemic myocardial injury Correlation

基金资助:辽宁省科学技术计划项目,(编号:2022-MS-430);辽宁省健康产业集团本钢总医院科研项目,(编号:034)

引用本文:

史艳红, 辛海岩, 林红. 脐动脉血气分析与新生儿缺氧缺血性心肌损伤的相关性研究[J]. 河北医学, 2025, 31(12): 2084-2089.
SHI Yanhong, XIN Haiyan, LIN Hong. Correlation between Umbilical Artery Blood Gas Analysis and Neonatal Hypoxic-Ischemic Myocardial Injury. HeBei Med, 2025, 31(12): 2084-2089.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2025.12.024 或 http://www.hbyxzzs.cn/CN/Y2025/V31/I12/2084

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