Effects of Conventional Drug Therapy Combined with Low-Frequency Repetitive Transcranial Magnetic Stimulation on Serum PGP MRP1 Protein and EEG in Patients with Refractory Epilepsy
YU Wenping, CHEN Fenfen, et al
Dai Zhuang Hospital, Shandong Jining 272051, China
Abstract：Objective: To investigate the effect of low frequency repetitive transcranial magnetic stimulation (lfms) on drug-resistant protein and electroencephalogram (EEG) in patients with intractable epilepsy. Methods: A total of 60 patients with intractable epilepsy from January 2023 to December 2023 in our hospital. The observation group was treated with low frequency repetitive transcranial magnetic stimulation (lfms) plus conventional antiepileptic drugs, while the control group was only treated with conventional antiepileptic drugs. The serum levels of p-glycoprotein (PGP) and multidrug resistance-associated protein 1(MRP1) were measured before and after 12 weeks of treatment, the clinical effect and the improvement of electroencephalogram were evaluated. Results: After 12 weeks of treatment, the levels of serum PGP and MRP1 protein in the observation group were significantly decreased, the number of attacks were significantly reduced, and the electroencephalogram discharge index was significantly decreased (P<0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05). The difference in the number of seizures between the two groups before and after treatment was statistically significant (P<0.05). There was a statistically significant difference in PGP serum levels between the two groups before and after treatment (P<0.05), while there was no statistically significant difference in MRP1 serum levels (P>0.05), indicating a greater impact on PGP and a smaller impact on MRP1. The improvement rate of electroencephalogram in the rTMS group was 80.0%, significantly higher than the 46.67% in the control group (P<0.05). Conclusion: Low-frequency repetitive transcranial magnetic stimulation combined with antiepileptic drugs can reduce the levels of serum PGP and MRP1 protein in patients with intractable epilepsy and reduce the number of seizures, and the treatment is relatively safe.
于文平, 陈粉粉, 孙凤春, 杜冬青. 常规药物治疗联合低频重复经颅磁刺激对难治性癫痫患者血清PGP MRP1蛋白及脑电图的影响[J]. 河北医学, 2025, 31(6): 959-963.
YU Wenping, CHEN Fenfen, et al. Effects of Conventional Drug Therapy Combined with Low-Frequency Repetitive Transcranial Magnetic Stimulation on Serum PGP MRP1 Protein and EEG in Patients with Refractory Epilepsy. HeBei Med, 2025, 31(6): 959-963.
2025, Vol. 31 
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