Abstract:Objective: To analyze the correlation between urinary albumin/creatinine ratio (UACR) and body mass index (BMI) and course of diabetes mellitus (DM) in elderly patients with DM, and analyze the risk factors affecting abnormal UACR. Methods: Totally 117 elderly patients with DM in the hospital from June 2024 to October 2024 were collected as the study subjects. The UACR of the subjects was measured, and the BMI and DM course were compared among patients with different levels of UACR. The correlation between UACR and BMI and DM course in elderly diabetic patients was explored by Pearson correlation analysis. The patients were divided into normal group (UACR< 30mg/g) and abnormal group (UACR≥30mg/g) based on the UACR level. Logistic regression analysis was utilized to analyze the risk factors affecting the abnormal UACR. Results: There were no obvious differences in age, gender, glycosylated hemoglobin, high density lipoprotein cholesterol, total cholesterol, and low density lipoprotein cholesterol between groups (P>0.05). The BMI, DM course, proportion of concurrent hypertension and triacylglycerol in the abnormal group were higher than those in the normal group (P<0.05). Logistic regression analysis found that BMI, DM course, concurrent hypertension, and triacylglycerol were independent risk factors for abnormal UACR (OR: 1.134, CI: 1.018~1.263; OR: 1.772, CI: 1.231~2.551; OR: 1.627, CI: 1.153~2.298; OR: 1.314, CI: 1.072~1.611, P<0.05). Conclusion: UACR in elderly patients with DM is closely related to BMI and course of DM. BMI, DM course, concurrent hypertension and triacylglycerol are independent risk factors for abnormal UACR. It is helpful for early detection of renal damage in elderly diabetic patients and guidance of the formulation of personalized treatment regimen.
田敏, 沈琼娜, 桑元康. 老年糖尿病患者UACR值与体重指数和糖尿病病程的相关性及UACR值异常的危险因素研究[J]. 河北医学, 2025, 31(8): 1330-1333.
TIAN Min, SHEN Qiongna, SANG Yuankang. Correlation of UACR with Body Mass Index and Course of Diabetes Mellitus in Elderly Diabetic Patients and Risk Factors of Abnormal UACR. HeBei Med, 2025, 31(8): 1330-1333.
[1] Rossing P,Baeres FMM,Bakris G,et al.The rationale,design and baseline data of FLOW,a kidney outcomes trial with once-weekly semaglutide in people with type 2 diabetes and chronic kidney disease[J].Nephrol Dial Transplant,2023,38(9):2041-2051. [2] Xie Y,Jin D,Qiu H,et al.Assessment of urinary podocalyxin as an alternative marker for urinary albumin creatinine ratio in early stage of diabetic kidney disease in older patients[J].Nefrologia (Engl Ed),2022,42(6):664-670. [3] Jongs N,Greene T,Chertow GM,et al.Effect of dapagliflozin on urinary albumin excretion in patients with chronic kidney disease with and without type 2 diabetes:a prespecified analysis from the DAPA-CKD trial[J].Lancet Diabetes Endocrinol,2021,9(11):755-766. [4] Polemiti E,Baudry J,Kuxhaus O,et al.BMI and BMI change following incident type 2 diabetes and risk of microvascular and macrovascular complications:the EPIC-Potsdam study[J].Diabetologia,2021,64(4):814-825. [5] Genco RJ,Graziani F,Hasturk H.Effects of periodontal disease on glycemic control,complications,and incidence of diabetes mellitus[J].Periodontol,2020,83(1):59-65. [6] 中华医学会,中华医学会杂志社,中华医学会全科医学分会,等.2型糖尿病基层诊疗指南(实践版·2019)[J].中华全科医师杂志,2019,18(9):810-818. [7] Wu Y,Sun Y,Wu Y,et al.Predictive value of ferroptosis-related biomarkers for diabetic kidney disease:a prospective observational study[J].Acta Diabetol,2023,60(4):507-516. [8] Elbarbary NS,Ismail EAR,Mohamed SA.Omega-3 fatty acids supplementation improves early-stage diabetic nephropathy and subclinical atherosclerosis in pediatric patients with type 1 diabetes:a randomized controlled trial[J].Clin Nutr,2023,42(12):2372-2380. [9] Kjaergaard AD,Teumer A,Witte DR,et al.Obesity and kidney function:a two-sample mendelian randomization study[J].Clin Chem,2022,68(3):461-472. [10] 曹哲,杨童悦,刘诗宇,等.肥胖人群尿白蛋白/肌酐比值异常的危险因素分析[J].中华内分泌代谢杂志,2024,40(3):186-191. [11] 李涛,张曼.基于Cox回归分析筛选2型糖尿病肾病发生的危险因素[J].标记免疫分析与临床,2023,30(10):1649-1653. [12] 夏阳阳,顾天伟,蒋春明,等.2型糖尿病患者发生慢性肾脏病的危险因素及与肥胖的相关性研究[J].中华糖尿病杂志,2022,14(2):140-146. [13] 叶丹玲,陶茜.不同阶段和不同病程糖尿病肾病患者血清和尿中NGAL表达对肾损伤的预测[J].中华实验外科杂志,2024,41(6):1180-1180.