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| Effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on the Inflammatory Factors of Severe Burn Patients and the Prevention of Sepsis |
| LIN Yan, RUAN Shubin, CHEN Xiaodong, et al |
| The First People's Hospital of Foshan, Guangdong Foshan 528000, China |
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Abstract Objective: To investigate the effect of ligustrazine injection on inflammatory cytokines in severe burn patients and the prevention of sepsis. Methods: 80 patients with severe burn admitted to our hospital from April 2013 to March 2017 were randomly divided into two groups. Patients in the control group were given routine treatment. Patients in the observation group were treated with ligustrazine injection. The two groups of patients with inflammatory factors, other diseases related parameters and sepsis prevention effect were compared. Results: The levels of TNF-α, IL-1, IL-6, CRP and PCT in the observation group were significantly lower than those in the control group on the 1st, 3rd, 7th, 10th and 14th day after treatment. ALT and AST levels were significantly lower than the control group, there was a significant difference (P <0.05); SIRS incidence was significantly lower than the control group, there was a significant difference (P <0.05). Conclusion: The effect of Salviae Miltiorrhizae injection on inflammatory factors and prevention of sepsis in patients with severe burn has significant reference value.
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[1] 张明,于燕,叶祥柏.丹参川芎嗪辅助治疗电弧烧伤的疗效分析[J].国际中医中药杂志,2015,37(6):505~508.
[2] 黄丹,段钰萍,王学东,等.丹参川芎嗪注射液对严重创伤患者炎性因子影响及预防脓毒症效果[J].现代中西医结合杂志,2017,26(10):1069~1071.
[3] 葛均波,徐永健主编.内科学[M].第8版.北京.人民卫生出版社,2013:297~368.
[4] Huang W,Yang Y,Zeng Z,et al.Effect of salvia miltiorrhiza and ligustrazine injection on myocardial ischemia/reperfusion and hypoxia/reoxygenation injury[J].Mol Med Rep,2016,14(5):4537~4544.
[5] 李纪伟,信艳艳.丹参川芎嗪注射液的临床应用研究[J].哈尔滨医药,2011,31(2):133,135.
[6] Zheng J,Ma L T,Ren Q Y,et al.Anti-fibrotic effects of salvia miltiorrhiza and ligustrazine injection on LX-2 cells involved with increased n-myc downstream-regulated gene 2 expression[J].Chin Integr Med,2017,23(12):923~928.
[7] 范文慧,裘五四.丹参川芎嗪注射液对急性颅脑损伤患者炎症因子的影响[J].中国临床药理学杂志,2017,33(12):1082~1084,1109.
[8] 何佳起,齐洪娜,张建军,等.心型脂肪酸结合蛋白和可溶性CD14亚型在丹参川芎嗪治疗脓毒症心肌损伤中的变化[J].实用医学杂志,2016,32(23):3924~3927 |
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2018, Vol. 24 
