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| Changes and Clinical Significance of CTC Level in Patients with Thyroid Cancer before and after 131I Treatment |
| DUAN Jun, XU Haiqing, LU Shuhua |
| Anqing Municipal Hospital, Anhui Anqing 246004, China |
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Abstract Objective: To investigate the changes in peripheral blood circulating tumor cell (CTC) levels in patients with thyroid cancer before and after iodine radioisotope (131I) treatment and to analyze their clinical significance.Methods: A total of 108 patients with thyroid cancer who were treated with 131I in the hospital from January to December 2022 were selected as the study subjects. According to the prognosis after 12 months of treatment, the patients were divided into a metastasis group (19 cases) and a non-metastasis group (89 cases). CTC levels before and after treatment and general information of the two groups were comparatively analyzed. Logistic regression analysis was conducted to screen the prognostic factors.Results: CTC levels before and after treatment were (15.51±1.67) FR/mL and (8.50±2.30) FR/mL, with a statistically significant difference (P<0.05). The difference in CTC level in the non-metastasis group before and after treatment was significantly higher than in the metastasis group (P<0.05). There was no statistically significant difference between the two groups in terms of age, gender, length of hospital stay, tumor type, tumor location, capsule invasion, T stage, residual thyroid mass, time from surgery to 131I treatment, frequency of 131I treatment, positive lymph nodes in the lateral cervical region, and Hashimoto's thyroiditis (P>0.05). The difference in the number of positive lymph nodes in the central cervical region was statistically significant (P<0.05). Logistic regression analysis found that the number of positive lymph nodes in the central cervical region was an independent influencing factor for the recurrence and metastasis of thyroid cancer after 131I treatment.Conclusion: 131I treatment after thyroidectomy can effectively improve CTC levels in patients with thyroid cancer, and the improvement of CTC levels before and after treatment is lower in patients with recurrence and metastasis. CTC helps predict recurrence and metastasis after thyroidectomy combined with 131I treatment. The number of positive lymph nodes in the central cervical region is an independent influencing factor for the recurrence and metastasis of thyroid cancer after 131I treatment.
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2024, Vol. 30 
