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| Efficacy of Insulin Aspart Combined with Insulin Detemir in the Treatment of Patients with GDM and the Effect on Serum NRG4, HGF and SAA Levels and Islet Cell Function |
| SHAO Xiaojie, ZHU Jie, et al |
| No.901 Hospital of Joint Logistics Support Force of the Chinese People's Liberation Army, Anhui Hefei 230031, China |
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Abstract Objective: To investigate the efficacy of insulin aspart combined with insulin detemir in the treatment of GDM and the effect on serum neuregulin 4 (NRG4), HGF, and amyloid A (SAA) levels and islet cell function.Methods: From June 2020 to June 2023, 113 patients with GDM were selected and randomly divided into the control group (n=56) and the observation group (n=57). The control group was treated with insulin aspart combined with premixed protamine recombinant human insulin while the observation group was treated with insulin aspart combined with insulin detemir. The two groups were compared on insulin use, time to blood glucose reaching the standard, blood glucose indicators (FBG, 2hPBG, and HbA1c), serum NRG4, HGF and SAA levels, islet cell function indicators [HOMA-IR, Homeostasis Model Assessment of beta-cell (HOMA-β) and fasting insulin (FINS)] and pregnancy outcomes. Results: The dosage of insulin and injection frequency in the observation group were lower than in the control group, and the time to blood glucose reaching the standard was shorter than that in the control group (P<0.05). The differences in FBG, 2hPBG, HbA1c, serum NRG4, HGF and SAA levels, HOMA-β, HOMA-IR, and FINS before and after treatment in the observation group were greater than those in the control group (all P<0.05). There was no statistically significant difference in the incidence rates of cesarean section, fetal macrosomia, neonatal hypoglycemia, and fetal distress between the two groups (P>0.05). Conclusion: The combined treatment with insulin aspart and insulin detemir has a significant therapeutic effect on GDM, which can control blood glucose, shorten the time for blood glucose to reach the standard, and improve serum NRG4, HGF, and SAA levels as well as islet cell function.
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2024, Vol. 30 
