血清IL-6 IL-17及IL-35水平与儿童急性淋巴细胞白血病病情及化疗疗效的研究

doi:10.3969/j.issn.1006-6233.2024.11.013

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Abstract Objective: To analyze the changes of serum interleukin-6 (IL-6), interleukin-17 (IL-17) and interleukin-35 (IL-35) levels in children with acute lymphoblastic leukemia (ALL) with different disease conditions and chemotherapy efficacy.Methods: A total of 95 children with ALL admitted to the hospital from October 2018 to October 2023 were divided into initial stage group (n=45) and advanced stage group (n=50) according to the severity of admission examination. By means of efficacy after 1 cycle of chemotherapy, they were classified into remission group (n=70) and non-remission group (n=25). Serum IL-6, IL-17 and IL-35 levels were measured among the study subjects. Binary Logistic regression analysis was used to construct an evaluation model with serum IL-6, IL-17 and IL-35 levels as variables. Receiver operating characteristic curve (ROC) was applied to analyze the evaluated value of serum IL-6, IL-17 and IL-35 on disease condition of children.Results: The levels of serum IL-6, IL-17 and IL-35 of advanced stage group were higher than initial stage group (P<0.05). Serum IL-6, IL-17 and IL-35 of non-remission group were higher than remission group (P<0.05). Logistic regression analysis indicated that serum IL-6, IL-17 and IL-35 were independent risk factors for disease progression of children with ALL, and the evaluation model was logit(P)=-7.052+0.206×IL-6+0.238×IL-17+0.406×IL-35. ROC analysis suggested the AUC of serum IL-6, IL-17 and IL-35 levels combined to evaluate the severity of childhood acute lymphoblastic leukemia was 0.918, the sensitivity was 80.00%, and the specificity was 95.56%, which was better than that of each index alone (P<0.05).Conclusion: Serum levels of IL-6, IL-17 and IL-35 are significantly different among ALL children with different disease conditions and chemotherapy efficacy. Early detection of serum IL-6, IL-17 and IL-35 can provide certain reference value for the evaluation of leukemia.

Key words： Acute lymphoblastic leukemia in children Interleukin-6 Interleukin-17 Interleukin-35 Chemotherapy efficacy

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.11.013 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I11/1830

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