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| Effectiveness of Dexmedetomidine Combined with Nalbuphine on Patients Undergoing Orthognathic Surgery and Its Impact on the Severity of Postoperative Nausea and Vomiting |
| DAI Weilan, et al |
| Affiliated Stomatological Hospital, Xiamen Medical College, Fujian Xiamen 361000, China |
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Abstract Objective: To explore the efficacy of dexmedetomidine combined with nalbuphine in patients undergoing orthognathic surgery (OGS) and its impact on the severity of postoperative nausea and vomiting (PONV). Methods: Ninety patients who underwent OGS in our hospital from August 2019 to December 2024 were randomly divided into a control group (n=45, receiving postoperative analgesia with sufentanil and nalbuphine) and a study group (n=45, receiving intraoperative infusion of dexmedetomidine and postoperative analgesia with sufentanil and nalbuphine) using a block randomization method. The satisfaction with analgesia, analgesic effect, sleep quality, severity of PONV, and incidence of agitation during the recovery period were compared between the two groups. Results: The overall satisfaction rate of pain relief in the research group (86.67%) was higher than that in the control group (64.44%) (P<0.05). Comparison of time-point, between-group, time-point and between-group interactions for visual analogue scale (VAS) and Pittsburgh Sleep Index (PSQI) scores showed statistical significance (P<0.05). The VAS scores of the study group were lower than those of the control group at 8, 16, 24, and 48 hours after surgery (P<0.05), and the PSQI scores of the study group were lower than those of the control group at 24 and 48 hours after surgery (P<0.05). The total incidence of PONV in the study group (11.11%) was lower than that in the control group (60.00%) within 0-12 hours after surgery. However, the total incidence of PONV in the study group (4.44%, 6.67%) within 12-24 hours and 24-48 hours after surgery was not statistically significant compared to the control group (11.11%, 8.89%) (P<0.05). The incidence of agitation during the awakening period in the study group was 6.67 (3/45), which was lower than the control group at 28.89% (13/45) (P<0.05). Conclusion: The combination of dexmedetomidine and nalbuphine in OGS patients can improve analgesic satisfaction, enhance analgesic efficacy and sleep quality, and reduce the severity of PONV and the incidence of agitation during the recovery period.
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2025, Vol. 31 
