血液透析患者血清hs-CRP Hcy MPO水平与冠状动脉粥样硬化的相关性分析

doi:10.3969/j.issn.1006-6233.2025.09.019

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Abstract Objective: To observe serum levels of high-sensitivity C-reactive protein (hs-CRP), homocysteine (Hcy) and myeloperoxidase (MPO) in hemodialysis patients, and analyze their correlation with coronary atherosclerosis. Methods: Totally 124 hemodialysis patients admitted to the Third People's Hospital of Chengdu from January 2021 to December 2023 were selected. According to the results of coronary artery angiography, the patients were divided into coronary atherosclerosis group and control group. General information and serum hs-CRP, Hcy and MPO levels of the two groups were compared. The risk factors for coronary artery atherosclerosis in hemodialysis patients were analyzed using multiple Logistic regression, and the correlation between serum hs CRP, Hcy, MPO levels and coronary artery atherosclerosis was analyzed using Spearman correlation analysis. Results: Among 124 hemodialysis patients, 51 (41.13%) had coronary atherosclerosis, while 73 (58.87%) had no coronary atherosclerosis. In the general information of the two groups of patients, there were statistically significant differences in dialysis age, systolic blood pressurethe, the levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) between the two groups (P<0.05). Compared to the control group, the coronary atherosclerosis group exhibited significantly higher levels of serum hs-CRP, Hcy, and MPO, with statistically significant differences (P<0.05). Logistic regression analysis showed that, LDL-C, HDL-C, hs-CRP, Hcy, and MPO levels were risk factors for coronary atherosclerosis in hemodialysis patients (P<0.05). Conclusion: The occurrence of coronary arteriosclerosis in hemodialysis patients is not only related to serum LDL-C and HDL-C, but also closely related to hs CRP, Hcy, and MPO levels. In clinical practice, high attention should be paid to the changes in serum LDL-C, HDL-C, hs CRP, Hcy, and MPO levels in hemodialysis patients to assess their risk of coronary arteriosclerosis as early as possible and take intervention measures.

Key words： Hemodialysis Coronary arteriosclerosis High-sensitivity C-reactive protein Homocysteine Plasma myeloperoxidase

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.09.019 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I9/1521

[1] 朱梦远,张翥,霍帅,等.视黄醇结合蛋白4与血液透析伴冠心病患者冠状动脉病变程度的相关性研究[J].中国临床医生杂志,2023,51(8):914-918.
[2] 杨晓亮,张荣军,王虎成,等.慢性肾功能衰竭患者合并脑出血的预后研究:一项单中心回顾性PSM研究[J].中华神经外科疾病研究杂志,2024,18(4):51-55.
[3] 贾蓉,薛建华,吴文,等.hs-CRP、NT-proBNP及NAR对急性冠状动脉综合征患者诊断价值分析[J].转化医学杂志,2024,13(2):208-211,217.
[4] Wu Y,Wang L,Zhan Y X C.The expression of SAH,IL-1 beta,Hcy,TNF-alpha and BDNF in coronary heart disease and its relationship with the severity of coronary stenosis[J].bmc cardiovascular disorders,2022,22(1):101.
[5] 上海市肾内科临床质量控制中心专家组.慢性肾脏病早期筛查、诊断及防治指南(2022年版)[J].中华肾脏病杂志,2022,38(5):453-464.
[6] 中华医学会心血管病学分会,中华心血管病杂志编辑委员会.中国慢性冠脉综合征患者诊断及管理指南[J].中华心血管病杂志,2024,52(6):589-614.
[7] Sicim H,Tang PC.Editorial commentary:Beware and avoid coronary-subclavian steal in hemodialysis patients undergoing CABG coronary-subclavian steal with CABG[J].Trends Cardiovasc Med,2024,34(3):191-192.
[8] 胡清芳,孙艳艳.维持性血液透析患者发生动脉硬化的危险因素及防治进展[J].中国血液净化,2024,23(1):46-49.
[9] Mazhar F,Hjemdahl P,Clase CM,et al.Intensity of and adherence to lipid-lowering therapy as predictors of major adverse cardiovascular outcomes in patients with coronary heart disease[J].Am Heart Assoc,2022,11(14):e025813.
[10] 谢嘉平,张波,尧鹏,等.维持性血液透析患者血清心肌肌钙蛋白T,hs- CRP表达与心血管并发症的关系研究[J].标记免疫分析与临床,2023,30(6):942-947.
[11] 鲁莉,王洁,卢青.血清IMA联合MPO诊断急性冠脉综合征的价值研究[J].华南国防医学杂志,2022,36(3):188-190,207.
[12] 袁志娟,程志强,高会文,等.非糖尿病维持性血液透析患者血清hs-CRP、Hcy、MPO水平及其与颈动脉硬化的相关性分析[J].临床和实验医学杂志,2022,21(1):44-47.
[13] Netto J,Teren A,Burkhardt R,et al.Biomarkers for non-invasive stratification of coronary artery disease and prognostic impact on long-term survival in patients with stable coronary heart disease[J].Nutrients,2022,14(16):3433.