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| Analysis of Correlation between Serum Vitamin A PCT and Hemoglobin Levels and Severity of Acute Pneumonia in Children |
| YAN Xinjie, SU Yanqi |
| General Hospital of Fukuang, Liaoning Health Industry Group / Seventh Clinical College of China Medical University, Liaoning Fushun113008, China |
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Abstract Objective: To analyze the correlation between levels of serum vitamin A (VA), procalcitonin (PCT) and hemoglobin (Hb) and disease severity of children pneumonia at acute stage. Methods: 76 children patients with pneumonia at acute stage in our hospital from August 2016 to August 2018 were included in observation group. According to the severity of disease, they were divided into mild group (n=31) and severe group (n=45) two subgroups. Another 30 healthy examiners at the same time period were included in control group (n=30). The levels of serum VA, PCT and Hb were compared between subgroups of observation group and between observation group and control group, and their correlation with disease severity was analyzed in children pneumonia at acute stage, and the receiver operating characteristic curve (ROC curve) was used to evaluate the diagnostic value of the above indicators on children pneumonia at acute stage. Results: The serum VA level in mild group was higher than that in severe group while the serum PCT level was lower than that in severe group (P<0.05). There was no significant difference in the Hb level between the two groups (P<0.05). The serum VA level in observation group was lower than that in control group while the serum PCT level was higher than that in control group (P<0.05). There was no significant difference in the Hb level between the two groups (P<0.05). The increases of serum VA and PCT levels were closely related to the occurrence of children pneumonia at acute stage (P<0.05). The ROC curve of VA showed AUC was 0.754 (P<0.05), with sensitivity of 0.526 and specificity of 0.900 respectively. The ROC curve of PTC showed AUC was 0.843 (P<0.05), with sensitivity of 0.855 and specificity of 0.767, respectively. The ROC curve of the two combination showed AUC was 0.872 (P<0.05) with sensitivity of 0.776 and specificity of 0.867, respectively, which were better than those of respective predictions (P<0.05). Conclusions: The decrease of serum VA and increase of PCT in children patients with pneumonia at acute stage are closely related to the progression of disease. The detection of indexes has certain value in evaluating patients’ condition and guiding clinical treatment.
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2019, Vol. 25 
