探讨儿童过敏性紫癜中ASO阳性与阴性患儿的临床及实验室特征差异

doi:10.3969/j.issn.1006-6233.2024.11.019

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Abstract Objective: To explore the correlation between streptococcal infections and the various classifications of Henoch-Schönlein Purpura (HSP) in children, focusing on associated clinical and laboratory parameters.Methods: From January 2021 to December 2023, 78 children diagnosed with HSP at Nanjing Gaochun People's Hospital were enrolled. They were divided into ASO positive and ASO negative groups for analysis of incidence rates and laboratory indicators. The children were further classified based on clinical manifestations into simple, joint, abdominal, renal, and mixed types. Additionally, 50 healthy children undergoing routine physical examinations at the same hospital were included as controls. Serum samples from all participants were tested for IgG and IgM antibodies, C4 complement levels, and throat swab cultures were performed to determine the relationship between streptococcal infection and HSP types.Results: The ASO positive group, generally older, showed significantly higher serum albumin levels (26.73±5.22 g/L) than the ASO negative group (23.45±4.88 g/L)(P<0.05), with no marked differences in urea and creatinine levels between the groups (P>0.05). Among immunoglobulin and complement levels, only IgA showed significant differences (P<0.05). IgG levels did not significantly vary among different HSP subtypes compared to controls, while IgM levels displayed significant differences (P<0.05). C4 levels were consistent across subtypes and controls (P>0.05). In terms of streptococcal types, type B hemolytic streptococcus appeared in 2.00% of the control group, and grass green streptococcus in 50.00%. Each HSP subtype had a distinct distribution of these bacteria, with type B hemolytic and grass green streptococci showing variable prevalence among the joint, abdominal, renal, and mixed types.Conclusion: This study substantiates a significant link between streptococcal infections and the subtypes of allergic purpura (HSP) in pediatric patients. The association of ASO titers with specific clinical features and laboratory markers underscores the critical role of streptococcal infection consideration in the diagnostic and treatment strategies for HSP. This underscores the need for vigilant monitoring and management of streptococcal infections to optimize outcomes for children with HSP.

Key words： Pediatric allergic purpura Streptococcus Anti streptococcal hemolysin O Association

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	ZHANG Huipin
	ZHANG Jianchun

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ZHANG Huipin,ZHANG Jianchun. Differences of Clinical and Laboratory Features between Positive andNnegative ASO in Children with Henoch-Schonlein Purpura[J]. HeBei Med, 2024, 30(11): 1858-1862.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.11.019 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I11/1858

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