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| Assessment of the Value of Laboratory Test Indicators for the Early Diagnosis of Neonatal Sepsis |
| YANG Qingyu, YANG Xu, LI Weichun |
| Chuzhou Hospital, Anhui Medical University, Anhui Chuzhou 239001, China |
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Abstract Objective: To analyze the clinical value of laboratory test indicators in the early diagnosis of neonatal sepsis (NS).Methods: Ninety-one patients with NS and 79 healthy infants treated in our hospital from September 2020 to October 2023 were enrolled in this research. The infants were divided into the control group (n=79) and sepsis group (n=91). The detection results of blood indexes were compared between the two groups. Multivariate logistic regression was used to identify the independent risk factors of NS. The receiver operating characteristic (ROC) curve was plotted to analyze the diagnostic value of laboratory indexes on NS.Results: The total number of white blood cells (WBC), neutrophilicgranulocyte (Neu), neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), procalcitonin (PCT), and C-reactive protein (CRP) in sepsis group were higher than those in control group (P<0.05), while the total number of lymphocyte (Lym) and lymphocyte-leukocyte ratio (LLR) were lower than those in control group (P<0.05), but there was no statistical difference in the total number of monocyte (Mono) between the two groups (P>0.05). Multivariate logistic regression analysis showed that WBC, Neu, Lym, PCT, and CRP were independent risk factors for neonatal NS (P<0.05). ROC curve analysis found that the area under the curve (AUC) of the combination of WBC, Neu, Lym, PCT, and CRP in predicting the occurrence of NS was the highest at 0.960, higher than that detected by the above indicators alone.Conclusion: WBC, Neu, Lym, PCT, and CRP are independent risk factors for neonatal NS, and combined detection has the highest efficiency in the early diagnosis of NS.
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2024, Vol. 30 
