病毒性与细菌性感染腹泻患儿外周血CD64指数 SAA STREM-1 CRP水平及临床意义

doi:10.3969/j.issn.1006-6233.2025.04.022

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Abstract Objective: To explore the peripheral blood CD64 index and serum amyloid A (SAA),soluble triggering receptor expressed on myeloid cells-1 (STREM-1) and C-reactive protein (CRP) levels and differential diagnostic value in children with infectious diarrhea caused by viral and bacterial infections. Methods: A total of 110 children with infectious diarrhea admitted from September 2022 to September 2024 were included in diarrhea group,and their fecal pathogen infection characteristics were analyzed.According to the types of pathogen infection,they were divided into viral group (viral infectious diarrhea,n=68) and bacterial group (bacterial infectious diarrhea,n=42).The baseline data and clinical indicators,peripheral blood CD64 index and serum SAA,STREM-1 and CRP were compared among the two groups of children.ROC curve was drawn to analyze the diagnostic and differential value of peripheral blood CD64 index,SAA,STREM-1 and CRP levels on the pathogenic infection types in children with infectious diarrhea. Results: Among the 110 children with infectious diarrhea,there were 68 cases (61.82%) of viral infection and 42 cases (38.18%) of bacterial infection.The proportion of watery stool and levels of WBC,IL-6,and PCT in viral group were significantly lower than those in bacterial group (P<0.05) while the proportion of organ injury was significantly higher than that in bacterial group (P<0.05).The CD6 index,SAA,STREM-1,and CRP in bacterial group were significantly higher than those in viral group (P<0.05).Using different pathogen types in children as state variables and CD6 index,SAA,STREM-1 and CRP as test variables,ROC curve results showed that the AUCs of CD6 index,SAA,STREM-1 and CRP in predicting bacterial diarrhea in children were 0.983,0.887,0.982 and 0.954 respectively,95%CI were(0.958~1.000,0.825~0.949,0.961~1.000 and 0.904~1.000). Conclusion: Peripheral blood CD64 index and serum SAA,STREM-1 and CRP levels can effectively distinguish bacterial diarrhea from viral diarrhea,and have reference value for the early differential diagnosis of infectious diarrhea caused by different pathogens.

Key words： Infectious diarrhea Amyloid A Soluble triggering receptor expressed on myeloid cells-1 C-Reactive protein Children

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	LIANG Yin
	JING Fangli
	TIAN Tian
	et al

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LIANG Yin,JING Fangli,TIAN Tian, et al. Exploring the Levels and Clinical Significance of CD64 Index SAA STREM-1 and CRP in Peripheral Blood of Children with Viral and Bacterial Diarrhea Infections[J]. HeBei Med, 2025, 31(4): 662-667.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.04.022 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I4/662

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