血清CCL19 HMGB1 IFN-γ对妊娠期系统性红斑狼疮患者围产结局预测价值

doi:10.3969/j.issn.1006-6233.2025.05.012

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Abstract Objective: To analyze the predictive value of serum chemokine ligand 19 (CCL19), high mobility protein-1 (HMGB1), and interferon - γ (IFN - γ) for perinatal outcomes in patients with systemic lupus erythematosus (SLE) during pregnancy. Methods: A total of 180 pregnant SLE patients treated in our hospital from January 2022 to January 2024 were selected and divided into an adverse group (n=41) and a good group (n=139) according to perinatal outcomes. Another 41 non-pregnant SLE patients treated in our hospital during the same period were selected as the control group. Serum levels of CCL19, HMGB1 and IFN-γ were compared between the three groups. logistic regression analysis was conducted to analyze the influencing factors of adverse perinatal outcomes in SLE patients during pregnancy, and the predictive efficacy of serum CCL19, HMGB1, and IFN-γ in SLE patients during pregnancy was analyzed by receiver operating curve (ROC). Results: Serum levels of CCL19, HMGB1 and IFN-γ in adverse group were higher than those in good group and control group (F=1184.610, 180.557, 487.362, P<0.05). Serum levels of CCL19, HMGB1 and IFN-γ in the good group were higher than those in the control group (P<0.05). Logistic regression analysis showed that, CCL19 [OR (95%CI): 2.036 (1.037~4.317)], HMGB1 [OR (95%CI): 1.982 (1.130~3.592)], IFN - γ [OR (95%CI): 3.936 (1.392~5.284)], Raynaud's phenomenon [OR (95%CI): 1.818 (1.057~3.269)], SLE disease activity score (SLEDAI)[OR (95%CI): 2.387 (1.047~4.082)] are risk factors for adverse perinatal outcomes in pregnant SLE patients (P<0.05). ROC curve analysis showed that the area under the curve (AUC) of the combined detection of serum CCL19, HMGB1, and IFN - γ for predicting adverse perinatal outcomes in pregnant SLE patients was 0.873, with a 95% confidence interval of 0.816~0.931. The AUC of the combined detection of serum CCL19, HMGB1, and IFN - γ was higher than that of single detection (Z/P=2.402/0.013, 2.598/0.009, 2.710/0.006). Conclusion: Overexpression of serum CCL19, HMGB1, and IFN - γ in pregnant SLE patients is closely associated with adverse perinatal outcomes. Combined detection of serum CCL19, HMGB1, and IFN - γ can improve the predictive power of adverse perinatal outcomes in pregnant SLE patients.

Key words： Systemic lupus erythematosus Chemokine ligand 19 High mobility protein-1 Interferon gamma Pregnancy Perinatal outcome

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.05.012 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I5/770

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