CalliSpheres载药微球-支气管动脉化疗栓塞联合免疫治疗晚期非小细胞肺癌患者的效果观察

doi:10.3969/j.issn.1006-6233.2025.05.030

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Abstract Objective: To observe the efficacy of CalliSpheres drug-eluting bead bronchial artery chemoembolization (DEB-BACE) combined with immunotherapy in advanced non-small cell lung cancer (NSCLC) patients. Methods: A retrospective analysis was performed on 142 advanced NSCLC patients admitted to our hospital from January 2020 to April 2023. Patients were divided into a control group (systemic chemotherapy combined with immunotherapy) and an observation group (CalliSpheres DEB-BACE combined with immunotherapy). Propensity score matching (caliper value set to 0.01, 1∶1 matching) was used, and 71 patients with comparable baseline data were finally included in each group. The efficacy on solid tumors, serum tumor markers [carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA-125), cytokeratin fragment antigen 21-1 (CYFRA21-1)] before and after treatment, T lymphocyte subsets (CD3⁺, CD4⁺, CD4⁺/CD8⁺), drug-related adverse reactions, and 1-year follow-up outcomes (progression-free survival, overall survival) were compared between the two groups. Results: The objective response rate (ORR) and disease control rate (DCR) in the observation group were 45.07% and 80.28%, respectively, significantly higher than 23.35% and 64.79% in the control group (P<0.05). Before treatment, there were no significant differences in CEA, CA125, and CYFRA21-1 levels between the two groups (P>0.05). After treatment, these markers decreased in both groups (P<0.05), with greater reductions observed in the observation group (P<0.05). Before treatment, CD4⁺, CD3⁺, and CD4⁺/CD8⁺ levels showed no significant differences (P>0.05). After treatment, CD4⁺, CD3⁺, and CD4⁺/CD8⁺ levels decreased in the observation group (P<0.05), with smaller changes compared to the control group (P>0.05). The incidence of bone marrow suppression was lower in the observation group (P<0.05). At 1-year follow-up, the observation group had a progression-free survival (PFS) of (10.12±0.31) months and an overall survival (OS) of (11.32±0.16) months, significantly better than the control group's PFS of (8.56±0.38) months and OS of (10.42±0.27) months (log rank χ²=6.416, P<0.05; log rank χ²=4.120, P=0.042). Conclusion: CalliSpheres DEB-BACE combined with immunotherapy is safe and effective for advanced NSCLC patients.

Key words： Non-small cell lung cancer Drug-eluting beads Transcatheter arterial chemoembolization Solid tumor efficacy Adverse reactions

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	ZHAN Ming
	ZHANG Mi
	ZHANG Haoyu
	et al

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ZHAN Ming,ZHANG Mi,ZHANG Haoyu, et al. Clinical Observation of CalliSpheres Drug-Eluting Bead Bronchial Artery Chemoembolization (DEB-BACE) Combined with Immunotherapy in Advanced Non-Small Cell Lung Cancer[J]. HeBei Med, 2025, 31(5): 871-876.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.05.030 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I5/871

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