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| Effect of Different Surgical Modalities for T1b Stage Renal Cancer on Patients' Postoperative Recurrence Metastasis and CTC |
| REN Lei, SHI Liang, YAN Qunfeng, et al |
| First People's Hospital of Xianyang City, Shaanxi Xianyang 712000, China |
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Abstract Objective: To investigate the influence of different surgical treatments on postoperative recurrence and metastasis and circulating tumor cell (CTC) in patients with stage T1b renal cell carcinoma (RCC). Methods: The case data of 88 patients with stage T1b RCC were retrospectively analyzed. According to different treatment methods, 42 patients undergoing partial nephrectomy were included in group A, and 46 patients receiving radical nephrectomy were enrolled as group B. The surgery-related indicators, renal function recovery conditions [estimated glomerular filtration rate (eGFR)], CTC level, postoperative recurrence and metastasis status [recurrence-free survival (RFS) rate within 3 years] and occurrence of postoperative complications were observed in the two groups. Results: There was no statistical difference in the intraoperative hemorrhagic fever time between groups (P>0.05). Compared with group B, group A had longer surgical time, less intraoperative estimated blood loss, and shorter postoperative hospital stay (P<0.05). eGFR level in group A at 1, 3 and 6 months after surgery had no statistical difference compared with that before surgery (P>0.05), eGFR level in group B at 1 month after surgery had no statistical difference compared to before surgery (P>0.05), and eGFR level at 3 and 6 months after surgery was decreased (P<0.05). The eGFR level in group A was not statistically different from group B at 1 month after surgery (P>0.05), and the eGFR level in group A was higher than that in group B at 3 and 6 months after surgery (P<0.05). The CTC count in both groups was increased at 7 days after surgery (P<0.05), but no statistical difference was shown in the CTC count at 3 months after surgery (P>0.05). The differences between the two groups were not statistical in terms of CTC count at various time points after surgery, RFS within 3 years and total incidence rate of postoperative complications (P>0.05). Conclusion: Both partial nephrectomy and radical nephrectomy are safe and effective in the treatment of patients with stage T1b RCC, with few postoperative complications. Both methods have the same effect on controlling tumor recurrence and metastasis. However, compared with radical nephrectomy, partial nephrectomy can better protect the renal function of patients and promote postoperative recovery.
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2025, Vol. 31 
