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| Effect of Polyene Phosphatidylcholine Injection Combined with Adenosylmethionine Butanedisulfonate on Liver Function, Albumin, and Coagulation Indicators in Patients with Liver Failure |
| YE Chong, WU Qianqian, LIU Changwei, et al |
| The First Affiliated Hospital of Anhui Medical University, Anhui Hefei 230022, China |
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Abstract Objective: To investigate the effects of polyene phosphatidylcholine injection combined with adenosylmethionine butanedisulfonate on liver function, albumin, and coagulation indicators in patients with liver failure. Methods: A total of 107 patients with liver failure treated at The First Affiliated Hospital of Anhui Medical University from December 2021 to December 2023 were selected and randomly divided into a control group (n=53, treated with polyene phosphatidylcholine injection) and a combined group (n=54, treated with polyene phosphatidylcholine injection combined with adenosylmethionine butanedisulfonate). The therapeutic effects, liver function, protein-related indicators, coagulation function, and complications of liver failure were compared between the two groups. Results: The total effective rate in the combined group (94.44%) was higher than in the control group (81.13%), with a statistically significant difference (P<0.05). After 4 weeks of treatment, the differences in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (TBIL) levels before and after treatment were greater in the combined group [(204.07±22.85) U/L, (151.45±30.16) U/L, (212.10±26.64) μmoL/L] compared to the control group [(189.23±24.70) U/L, (123.03±29.48) U/L, (196.59±23.20) μmoL/L], with statistical significance (P<0.05). The combined group also showed significantly higher improvements in serum total protein (TP), albumin (ALB), and prealbumin (PA) levels [(7.41±2.26) g/L, (8.53±2.08) g/L, (55.24±10.72) mg/L] compared to the control group [(2.64±1.69) g/L, (4.56±1.75) g/L, (36.18±11.82) mg/L] (P<0.05). Additionally, fibrinogen (FIB), prothrombin activity (PTA), and D-dimer (D-D) improvements in the combined group [(0.55±0.17) g/L, (24.89±3.92)%, (1.21±0.44) mg/L] were greater than those in the control group [(0.34±0.20) g/L, (18.33±4.06)%, (1.02±0.35) mg/L] (P<0.05). The incidence of complications of liver failure was not significantly different between the two groups (P>0.05). Conclusion: The combination of polyene phosphatidylcholine injection and adenosylmethionine butanedisulfonate improves liver and coagulation function in patients with liver failure. The combined treatment is more effective than monotherapy.
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2024, Vol. 30 
