癫痫持续状态患者神经元特异烯醇化酶白细胞介素水平与脑电图异常程度的相关性

doi:10.3969/j.issn.1006-6233.2025.10.023

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摘要 目的: 观察癫痫持续状态患者神经元特异烯醇化酶(NSE)、白细胞介素-6(IL-6)水平与脑电图异常程度的相关性。方法: 选取2023年1月至2023年12月内蒙古兴安盟人民医院收治的癫痫持续状态患者103例,作为癫痫持续状态组,另外选取同期健康体检者100例作为对照组,比较两组血清NSE、IL-6水平,并根据癫痫持续状态组脑电图结果分为正常组、轻度异常组、中度异常组及重度异常组,展开单因素与多因素分析,评估癫痫患者脑电图异常程度主要影响因素,并分析血清NSE、IL-6水平与脑电图异常程度的相关性。结果: 癫痫持续状态组患者血清NSE、IL-6水平均高于对照组(P<0.05)。不同脑电图异常程度患者癫痫发作频率、癫痫发作类型、血清NSE、IL-6水平比较差异有统计学意义(P<0.05),癫痫发作频率、血清NSE、IL-6水平比较,重度异常组>中度异常组>轻度异常组>正常组(P<0.05);重度异常组全面性发作占比高于其他三组(P<0.05),中度异常组全面性发作占比高于正常组与轻度异常组(P<0.05);经多因素分析,癫痫发作频率、癫痫发作类型、血清NSE、IL-6水平均为癫痫患者脑电图异常独立影响因素(P<0.05);Spearman相关性显示,癫痫持续状态患者血清NSE、IL-6水平与脑电图异常程度呈正相关(P<0.05)。结论: 癫痫持续状态患者脑电图异常程度与癫痫发作频率、癫痫发作类型、NSE、IL-6有关,且血清NSE、IL-6水平与患者脑电图异常程度呈正相关,建议予以密切关注。

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关键词 ：癫痫持续状态, 神经元特异烯醇化酶, 白细胞介素-6, 脑电图, 相关性

Abstract：Objective: To observe the correlation of the levels of neuron-specific enolase (NSE) and interleukin-6 (IL-6) with the degree of EEG abnormalities in patients with status epilepticus. Methods: A total of 103 patients with status epilepticus (status epilepsy group) admitted to Inner Mongolia Xingan League People's Hospital from January to December 2023, and 100 healthy individuals (control group) who received health check-ups during the same period were enrolled in the study. Serum NSE and IL-6 levels in the two groups were compared. Patients in the status epilepsy group were divided into the normal group, the mild abnormality group, the moderate abnormality group, and the severe abnormality group based on EEG examination results. Univariate and multivariate analyses were conducted to evaluate the main influencing factors of EEG abnormalities in patients with epilepsy. Serum NSE and IL-6 levels in patients with different degrees of EEG abnormalities were compared. The correlation between serum NSE and IL-6 levels and the degree of EEG abnormalities was analyzed. Results: Serum NSE and IL-6 levels were higher in the status epilepsy group than in the control group (P<0.05). There were significant differences in epileptic seizure frequency and seizure type, and serum NSE and IL-6 levels among patients with different degrees of EEG abnormalities (P<0.05). Seizure frequencies and serum NSE and IL-6 levels in the severe abnormality group, the moderate abnormality group, the mild abnormality group, and the normal group decreased in order (P<0.05). The proportion of generalized seizures in the severe abnormality group was higher than those in the other three groups (P<0.05). and the proportion of generalized seizures in the moderate abnormality group was higher than those in the normal group and the mild abnormality group (P<0.05). Multivariate analysis found that epileptic seizure frequency, seizure type, serum NSE, and IL-6 levels were independent influencing factors of EEG abnormalities in patients with epilepsy (P<0.05). Spearman correlation analysis found that serum NSE and IL-6 levels in patients with status epilepticus were positively correlated with the degree of EEG abnormalities (P<0.05). Conclusion: The degree of EEG abnormality is related to epileptic seizure frequency, seizure type, NSE, and IL-6 in patients with status epilepticus. Moreover, serum NSE and IL-6 levels are positively correlated with the degree of EEG abnormality, which deserves close attention.

Key words： Status epilepticus Neuron-specific enolase Interleukin-6 Electroencephalogram Correlation

引用本文:

白文婷, 孙畅, 陈敬敏, 孙丽峰, 何芳包洪靖, 张学齐, 海力瀚, 胡志臣, 赵立慧. 癫痫持续状态患者神经元特异烯醇化酶白细胞介素水平与脑电图异常程度的相关性[J]. 河北医学, 2025, 31(10): 1718-1723.
BAI Wenting, SUN Chang, CHEN Jingmin, et al. Correlation of the Levels of Neuron-Specific Enolase and Interleukin with the Degree of EEG Abnormalities in Patients with Status Epilepticus. HeBei Med, 2025, 31(10): 1718-1723.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2025.10.023 或 http://www.hbyxzzs.cn/CN/Y2025/V31/I10/1718

[1] 赵妍,李梦珂,凌云,等.吡仑帕奈治疗儿童难治性癫痫的效果及机制[J].西北药学杂志,2023,38(6):132-136.
[2] Cavusoglu D,Olgac Dundar N,Kamit F,et al.Evaluation of nonconvulsive status epilepticus and nonconvulsive seizures in a pediatric intensive care unit[J].Clin Pediatr (Phila),2023,62(8):879-884.
[3] Li J,Qi Z,Chen M,et al.Clinical value of combined serum CA125,NSE and 24-hour urine VMA for the prediction of recurrence in children with neuroblastoma[J].Ital Pediatr,2023,49(1):102.
[4] 陈睿,薛国芳.NLRP3炎症小体在癫痫发生神经炎症中的研究进展[J].中国实用神经疾病杂志,2024,27(1):128-132.
[5] 中国抗癫痫协会.临床诊疗指南-癫痫病分册(2023修订版)[M].人民卫生出版社,2023.
[6] Borges DF,Primicerio G,Perjoc RS,et al.The dianalund experience: a review of the 6th ILAE school on advanced EEG and epilepsy[J].Epileptic Disord,2024,26(6):898-901.
[7] 潘东,段英杰.急性缺血性脑卒中患者血清CTRP-9、NSE水平与神经功能缺损程度及卒中后认知障碍发生的关系[J].山东医药,2023,63(17):61-64.
[8] 邓会芳,王博,孙婧,等.成人超难治性癫痫持续状态治疗的研究进展[J].卒中与神经疾病,2024,31(1):109-111.
[9] Chand P,Angez M,Hameed AN,et al.Potassium channel subfamily T member 1(KCNT1) pathological variant causing epilepsy of infancy with migrating focal seizures: a case report[J].Pak Med Assoc,2023,73(8):1720-1722.
[10] Surina NM,Fedotova IB,Nikolaev GM,et al.Neuroinflammation in pathogenesis of audiogenic epilepsy: altered proinflammatory cytokine levels in the rats of krushinsky-molodkina seizure-prone strain[J].Biochemistry (Mosc),2023,88(4):481-490.
[11] 孙卫进,苏文龙,李晓莉,等.植入式迷走神经刺激治疗儿童全面发作性癫痫的疗效及预后因素分析[J].临床神经外科杂志,2025,22(1):14-19.
[12] Dunbabin I,Banez RM,de Souza A.Dural arteriovenous fistula presenting with recurrent focal status epilepticus and lateralised periodic epileptiform discharges[J].Neurol Sci,2024,45(4):1741-1748.
[13] Budhram A,Burneo JG.Acute symptomatic seizures,epilepsy,and autoimmune encephalitis: clarifying terminology in neural antibody-associated disease[J].Epilepsia,2023,64(2):306-310.