NCPAP NIPPV分别联合牛肺表面活性剂治疗新生儿呼吸窘迫综合征的对比研究

doi:10.3969/j.issn.1006-6233.2026.01.026

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摘要 目的: 分析经鼻持续气道正压通气(NCPAP)、经鼻间歇正压通气(NIPPV)分别联合牛肺表面活性剂对新生儿呼吸窘迫综合征(NRDS)的效果。方法: 回顾性将2022年6月至2024年5月于本院出生的120例呼吸窘迫综合征患儿按照治疗方法分为NCPAP组(n=58,NCPAP模式+牛肺表面活性剂)和NIPPV组(n=62,NIPPV模式+牛肺表面活性剂)。对比两组无创通气时间、总用氧时间、住院时间,观察两组的治疗前后动脉血气指标、炎症反应指标,比较两组的并发症情况。结果: NIPPV组的无创通气时间、住院时间短于NCPAP组(P<0.05),两组总用氧时间比较差异无统计学意义(P>0.05);与NCPAP组相比,NIPPV组治疗后24h的动脉血二氧化碳分压(PaCO₂)较NCPAP组低、动脉血氧分压(PaO₂)、pH值较NCPAP组高(P<0.05);治疗后3d,两组的白介素-6(IL-6)、降钙素原(PCT)、C反应蛋白(CRP)水平降低(P<0.05),但两组间比较差异无统计学意义(P>0.05);两组并发症比较差异无统计学意义(P>0.05)。结论: 相较于NCPAP模式联合牛肺表面活性剂,NIPPV模式联合牛肺表面活性剂治疗可缩短NRDS无创通气时间及住院时间,改善血气指标。

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关键词 ：呼吸窘迫综合征, 新生儿, 牛肺表面活性剂

Abstract：Objective: To analyze the effect of nasal continuous positive airway pressure (NCPAP) or nasal intermittent positive pressure ventilation (NIPPV) combined with bovine pulmonary surfactant on neonatal respiratory distress syndrome (NRDS). Methods: 120 children with respiratory distress syndrome, born in the hospital from June 2022 to May 2024, were divided into the NCPAP group (n=58, NCPAP mode + bovine lung surfactant) and the NIPPV group (n=62, NIPPV mode + bovine lung surfactant) according to the treatment methods. The noninvasive ventilation time, total oxygen use time and hospitalization time were compared between both groups. The arterial blood gas indexes and inflammatory response indexes in the two groups were observed before and after treatment, and the complications were compared. Results: NIPPV group showed shorter noninvasive ventilation time and hospitalization time than NCPAP group (P<0.05). There was no statistically significant difference in the total oxygen usage time between the two groups (P>0.05). The arterial partial pressure of carbon dioxide (PaCO₂) in NIPPV group at 24 hours after treatment was lower while the arterial partial pressure of oxygen (PaO₂) and pH value were higher compared to NCPAP group (P<0.05). The levels of interleukin-6 (IL-6), procalcitonin (PCT) and C-reactive protein (CRP) in two groups were decreased at 3 days after treatment (P<0.05), and the above levels exhibited no statistical differences between groups (P>0.05). The differences in complications were not statistically significant between groups (P>0.05). Conclusion: Compared with NCPAP model combined with bovine pulmonary surfactant, NIPPV model combined with bovine pulmonary surfactant can better shorten the NRDS noninvasive ventilation time and hospitalization time, and improve the blood gas indexes.

Key words： Respiratory distress syndrome Neonates Bovine pulmonary surfactant

基金资助:2023年度安徽省卫生健康科研项目,(编号:AHWJ2023A10138)

引用本文:

张瑞, 黄金, 李莹莹, 梅珍珠, 张晶玲. NCPAP NIPPV分别联合牛肺表面活性剂治疗新生儿呼吸窘迫综合征的对比研究[J]. 河北医学, 2026, 32(1): 163-167.
ZHANG Rui, HUANG Jin, LI Yingying, et al. Comparative Study of NCPAP Model or NIPPV Model Combined with Bovine Pulmonary Surfactant in Treating Neonatal Respiratory Distress Syndrome. HeBei Med, 2026, 32(1): 163-167.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2026.01.026 或 http://www.hbyxzzs.cn/CN/Y2026/V32/I1/163

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