Analysis of the Correlation and Predictive Value of Cytokine Levels with Postoperative Recurrence and Bone Metastasis in Patients with Prostate Cancer after Radical Prostatectomy
ZHANG Yanhong, CHEN Na, WANG Wei, et al
Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Abstract：Objective: To investigate the correlation between cytokine levels and postoperative recurrence and bone metastasis in prostate cancer (PCa) patients, as well as their clinical predictive value. Methods: A retrospective collection of clinical data from 134 patients with prostate cancer who underwent radical prostatectomy (RP) from August 2021 to August 2024 was conducted. These patients were divided into a recurrence group (54 cases) and a non-recurrence group (80 cases) based on whether they had recurrence. Among the recurrence group, patients were further divided into a bone metastasis group (23 cases) and a non-bone metastasis group (31 cases) according to the type of recurrence. Multivariate Logistic regression model was used to screen the influencing factors of bone metastasis in patients after RP, and ROC curve was used to evaluate the predictive efficacy of related indicators. Results: The preoperative levels of prostate-specific antigen (PSA) and Leptin, postoperative Gleason score, interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), and tumor necrosis factor-α (TNF-α) in the recurrence group were higher than those in the non-recurrence group (P<0.05). Among the patients with recurrence, those in the bone metastasis group had significantly higher preoperative PSA levels, Leptin levels, and postoperative levels of transforming growth factor-β1 (TGF-β1), IL-6, and TNF-α compared with the non-bone metastasis group (P<0.05). The results of multivariate logistic regression analysis showed that postoperative TNF-α level was an independent influencing factor (P <0.05). ROC curve analysis showed that the AUC of TNF-α for predicting bone metastasis was 0.915. At the cut-off value of 15.52 pg/mlL, the sensitivity was 90.3%, the specificity was 91.3%, the positive predictive value was 87.5%, the negative predictive value was 93.3%, and the accuracy was 90.7%. Conclusion: Postoperative serum TNF-α level is an independent predictive indicator for postoperative recurrent bone metastasis in PCa patients, with high clinical application value, and can be used as an important biological marker for evaluating the risk of postoperative bone metastasis.
张艳红, 陈娜, 王薇, 王倩, 孙齐蔓. 细胞因子水平与前列腺癌患者术后复发及骨转移的相关性及预测价值分析[J]. 河北医学, 2025, 31(11): 1862-1867.
ZHANG Yanhong, CHEN Na, WANG Wei, et al. Analysis of the Correlation and Predictive Value of Cytokine Levels with Postoperative Recurrence and Bone Metastasis in Patients with Prostate Cancer after Radical Prostatectomy. HeBei Med, 2025, 31(11): 1862-1867.
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2025, Vol. 31 
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