青海不同海拔地区藏族2型糖尿病患者血清瘦素游离脂肪酸和脂联素水平与胰岛素抵抗的关系

doi:10.3969/j.issn.1006-6233.2025.08.016

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摘要目的:探讨青海不同海拔地区藏族2型糖尿病患者血清瘦素、游离脂肪酸(FFA)和脂联素水平与胰岛素抵抗的关系。方法:回顾性分析2022年10月至2024年7月我院就诊的80例藏族2型糖尿病患者的病历资料,根据患者所在地区海拔的不同将41例患者纳入高海拔地区组(≥3000米),将39例患者纳入低海拔地区组(<3000米),检测血清瘦素、FFA、脂联素水平及胰岛素抵抗指数(HOMA-IR),分析两组上述指标水平的差异,采用Pearson相关性分析比较血清瘦素、FFA、脂联素水平与胰岛素抵抗的相关性,并对比两组中各指标与HOMA-IR的关联强度。结果:高海拔地区组血清瘦素水平、血清FFA水平、HOMA-IR均高于低海拔地区组,差异有统计学意义(P<0.05);高海拔地区组脂联素水平低于低海拔地区组,差异有统计学意义(P<0.05);血清瘦素、FFA水平与HOMA-IR在两组中均呈正相关(P<0.05),脂联素水平与HOMA-IR在两组中均呈负相关(P<0.05),从r值的分布来看,高海拔地区的关联效应更强,但两组间的差异经比较,未呈现出统计学意义(P>0.05)。结论:高海拔地区的藏族2型糖尿病患者中,血清瘦素水平与FFA水平呈现较高态势,而脂联素水平则相对较低,且无论是高海拔地区还是低海拔地区,上述指标都与胰岛素抵抗有紧密的关联,尚未发现不同海拔地区关联强度上的差别。

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关键词 ： 2型糖尿病, 不同海拔地区, 藏族, 血清瘦素, 胰岛素抵抗

Abstract：Objective: To investigate the relationship between levels of serum leptin, free fatty acid (FFA) and adiponectin and insulin resistance in Tibetan patients with type 2 diabetes mellitus (T2DM) at different altitudes in Qinghai. Methods: The medical records of 80 Tibetan patients with T2DM in the hospital were retrospectively analyzed from October 2022 to July 2024. According to the different altitudes of the patients, 41 cases were included in high altitude group ( ≥3000 meters), and 39 cases were enrolled as low altitude group (<3000 meters). Serum leptin, FFA, adiponectin and insulin resistance index (HOMA-IR) were detected. The differences in the above indicators were analyzed in the two groups. The correlation between serum leptin was explored by using Pearson correlation analysis., FFA and adiponectin and insulin resistance and to compare the correlation strength between indicators and HOMA-IR in the two groups. Results: The levels of serum leptin and serum FFA and HOMA-IR in high altitude group were higher than those in low altitude group (P<0.05), while the adiponectin level was lower than that in low altitude group (P<0.05). Serum leptin and FFA levels were positively correlated with HOMA-IR in both groups (P<0.05), and adiponectin level was negatively correlated with HOMA-IR in both groups (P<0.05). From the distribution of r value, the correlation effect in high altitude areas was stronger, nevertheless, there was no statistically significant difference between the groups (P>0.05). Conclusion: In Tibetan patients with T2DM in high altitude areas, serum leptin level and FFA level show high trends, while adiponectin level is relatively low, and the above indicators are closely related to insulin resistance in both high altitude and low altitude areas, no difference in the strength of association has been found between different altitude regions.

Key words： Type 2 diabetes mellitus Different altitudes Tibetan Serum leptin Insulin resistance

基金资助:青海省卫生健康委员会指导性计划课题项目,(编号:2022-wjzdx-70)

引用本文:

李玉英, 马明福, 魏雪芳, 王丽. 青海不同海拔地区藏族2型糖尿病患者血清瘦素游离脂肪酸和脂联素水平与胰岛素抵抗的关系[J]. 河北医学, 2025, 31(8): 1326-1330.
LI Yuying, et al. Relationship between Serum Leptin Free Fatty Acid and Adiponectin Levels and Insulin Resistance in Tibetan Patients with T2DM at Different Altitudes in Qinghai. HeBei Med, 2025, 31(8): 1326-1330.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2025.08.016 或 http://www.hbyxzzs.cn/CN/Y2025/V31/I8/1326

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